Powder properties and their influence on dry powder inhaler delivery of an antitubercular drug
نویسندگان
چکیده
منابع مشابه
Dry powder inhaler formulation.
A drug product combines pharmacologic activity with pharmaceutical properties. Desirable performance characteristics are physical and chemical stability, ease of processing, accurate and reproducible delivery to the target organ, and availability at the site of action. For the dry powder inhaler (DPI), these goals can be met with a suitable powder formulation, an efficient metering system, and ...
متن کاملDry powder inhaler device influence on carrier particle performance.
Dry powder inhalers (DPIs) are distinguished from one another by their unique device geometries, reflecting their distinct drug detachment mechanisms, which can be broadly classified into either aerodynamic or mechanical-based detachment forces. Accordingly, powder particles experience different aerodynamic and mechanical forces depending on the inhaler. However, the influence of carrier partic...
متن کاملDry powder inhalers for pulmonary drug delivery.
The pulmonary route is an interesting route for drug administration, both for effective local therapy (asthma, chronic obstructive pulmonary disease or cystic fibrosis) and for the systemic administration of drugs (e.g., peptides and proteins). Well-designed dry powder inhalers are highly efficient systems for pulmonary drug delivery. However, they are also complicated systems, the the performa...
متن کاملDry powder cationic lipopolymeric nanomicelle inhalation for targeted delivery of antitubercular drug to alveolar macrophage
Excipients having self-assembling properties are less explored in the field of dry powder inhalation (DPI) technology. An amphiphilic lipopolymer system was developed using stearic acid (SA) and branched polyethyleneimine (BPEI) (1800 Dalton), at different proportions by covalent conjugation. A molecular dynamic (MD) simulation tool was employed for predicting the carrier behavior in a polar in...
متن کاملCiprofloxacin dry powder inhaler in cystic fibrosis.
Correspondence to Professor J Stuart Elborn; [email protected] Inhaled antibiotics are the backbone of care for people with cystic fibrosis (CF) who have lung infection due to Pseudomonas aeruginosa. They have significantly contributed to the improved quality of life (QOL) and increased survival in people with this disease. The systematic application of antibiotic eradication therapy for new o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2002
ISSN: 1530-9932
DOI: 10.1208/pt030428